Patient receiving treatment

HDx Therapy Enabled by the Theranova Dialyzer

One step closer to the natural kidney.1

A clinician's perspective

“Since swapping to Theranova, we have had a reduction in medication costs and hospitalizations.2-7 ... It made sense financially, it made sense for our clinic and for our quality measures. ... I feel like Theranova is a no-brainer.”

Sarah Walls, RN, Director of Dialysis

See the evidence
See the evidence

Go beyond urea. One effortless dialyzer switch could make a world of difference for your patients.

One step closer to the natural kidney 1

HDx therapy enabled by Theranova Dialyzers delivers superior removal of large-middle molecules compared to both conventional (high-flux) HD and HDF therapies, while maintaining stable serum albumin levels and without changing current HD machines and workflow.8,9

HDx therapy vs. high-flux HD and HDF
Patient receiving treatment
HDx therapy vs. high-flux HD and HDF

See how the Theranova Dialyzer works

Download the brochure and datasheet to discover how Theranova Dialyzer brings us a step closer to the natural kidney.1

Brochure Datasheet
A healthcare professional holds a Theranova dialyzer by a AK 98 machine
Brochure Datasheet

Choosing the Theranova Dialyzer may help reduce hospitalizations, medication usage and cost of care compared to high-flux HD

  • Up to 45% reduction in all-cause hospitalizations2
  • Up to $4,772 lower cost per patient, with savings demonstrated in 96% of the 10,000 simulations in a probability analysis of mean cost difference2
    • Randomized controlled trial of US hemodialysis patients
  • Reduced erythropoietin resistance and ESA utilization3-5,10
  • Decreased dosing of supportive medications such as iron, insulin and antihypertensive medications4,5
    • Multicenter, observational study; retrospective analysis; and prospective, randomized, controlled, open-label studies
Study summary: Hospitalizations and costs Study compendium: Economic outcomes

Patient-reported quality of life may improve using the Theranova Dialyzer compared to high-flux HD

  • Improved effects and burden of kidney disease11
    • Prospective, multicenter, observational study
  • Improved sleep quality, energy level, and general well-being12
    • Single center, unblinded, exploratory pilot study
Study summary: Burden of kidney disease Study summary: Well-being, energy and sleep

Additional studies detailing positive patient outcomes

Up to 2.5 hours reduction in patient-reported dialysis recovery time13

Single center, retrospective analysis

Study summary: Dialysis recovery time

Reduction in patient-reported pruritus14

Randomized, prospective, controlled, open-label study

Study summary: Pruritus

Up to 55% reduction in patients meeting diagnostic criteria for restless leg syndrome (RLS)11

Prospective, multicenter, observational study

Study summary: RLS

Patient stories

Hear from patients on their experiences with HDx therapy

“

... when I told (my doctor) about (my restless leg syndrome), she had the idea to switch me over to Theranova Dialyzer. And after that, I got better. That was amazing. And I could finally sleep again. Sleep peacefully. All the symptoms have completely changed with the new dialyzer. It gave me a new lease of life.

Andre, patient on HDx therapy

“

I feel, in myself, Theranova definitely made an impact on my family life, home life and all parts of my life. I can do things that I couldn't do ... I go take my kids out to the park.

Dennis, patient on HDx therapy

“

When we started dialysis with the new Theranova Dialyzer, after a few weeks, like within 2 months, I can see that her itchiness has reduced by 90%, and after like four months, there is no itchiness, ... she doesn't scratch. ... That is like a result that you can see.

Shatila, caregiver for mother on HDx therapy

“

... couple days after using it, ... I started to feel better ... I was eating a little better, and my sleep wasn't great, but it was way better, much improved. So, I thought, boy, this is ridiculous. Then I started thinking — wait a minute — this is not imaginary ... obviously there is a difference in the dialyzer.

Robert, patient on HDx therapy

Healthcare professional sitting at table on laptop

Access our Medical Channel to learn more on HDx therapy from healthcare professionals

Look for webinars and resources on HDx therapy, delivering expanded hemodialysis, in the Medical Channel. 

Note: No registration key is required.

Register or sign in

Learn more

See how Vantive’s Theranova dialyzer enables HDx therapy, delivering expanded hemodialysis.

Theranova Dialyzers for HDx therapy

Important Safety Information

INTENDED USE

The Theranova Dialyzer is indicated for patients with chronic kidney failure who are prescribed intermittent hemodialysis. It provides an expanded solute removal profile with increased removal of various middle molecules (up to 45 kDa) that may play a pathologic role in the uremic clinical syndrome. The Theranova Dialyzer is not intended for hemofiltration or hemodiafiltration therapy. The total extracorporeal blood volume for the Theranova Dialyzer and the set should represent less than 10% of the patient's blood volume.

For single use only.

Rx Only. For safe and proper use of the products mentioned herein, please refer to the appropriate Operator’s Manual or Instructions for Use.

Vantive, HDx, MCO and Theranova are trademarks of Vantive Health LLC or its affiliates.

References

  1. Zweigart C, Boschetti-de-Fierro A, Hulko M, et al. Medium cut-off membranes — closer to the natural kidney removal function. Int J Artif Organs. 2017; 40(7):328-334.

  2. Blackowicz MJ, Falzon L, Beck W, Tran H, Weiner DE. Economic evaluation of expanded hemodialysis with the Theranova 400 dialyzer: A post hoc evaluation of a randomized clinical trial in the United States. Hemodial Int. 2022;26:449-455.

  3. Hadad-Arrascue F, Nilsson LG, Rivera AS, Bernardo AA, Cabezuelo Romero JB. Expanded hemodialysis as effective alternative to on-line hemodiafiltration: A randomized mid-term clinical trial. Ther Apher Dial. 2022;26(1):37-44.

  4. Ariza JG, Walton SM, Suarez AM, Sanabria M, Vesga JI. An initial evaluation of expanded hemodialysis on hospitalizations, drug utilization, costs, and patient utility in Colombia. Ther Apher Dial. 2021;25(5):621-627.

  5. Sanabria RM, Hutchison CA, Vesga, JI, Ariza JG, Sanchez R, Suarez AM. Expanded hemodialysis and its effects on hospitalizations and medication usage: A  cohort study. Nephron. 2021;145(2):179-187.

  6. Molano-Triviño A, Sanabria M, Vesga J, Buitrago G, Sánchez R, Rivera A. Effectiveness of medium cut-off vs high flux dialyzers: a propensity score matching cohort study. Nephrol Dial Transplant. 2021;36(suppl 1):486.

  7. Cozzolino M, Magagnoli L, Ciceri P, Conte F, Galassi A. Effects of a medium cut-off (THERANOVA®) dialyser on haemodialysis patients: a prospective, cross-over study. Clin Kidney J. 2021;14(1):382-389.

  8. Theranova Instructions for Use, 2021.

  9. Kirsch AH, Lyko R, Nilsson LG, et al. Performance of hemodialysis with novel medium cut-off dialyzers [published correction appears in Nephrol Dial Transplant. 2021 Jul 23;36(8):1555-1556]. Nephrol Dial Transplant. 2017;32(1):165-172.

  10. Lim JH, Jeon Y, Yook JM, et al. Medium cut-off dialyzer improves erythropoiesis stimulating agent resistance in a hepcidin-independent manner in maintenance hemodialysis patients: results from a randomized controlled trial. Sci Rep. 2020;10(1):1-10.

  11. Alarcon JC, Bunch A, Ardila F, et al. Impact of medium cut-off dialyzers on patient-reported outcomes: COREXH Registry. Blood Purif. 2021;50(1):110–118.

  12. Penny JD, Jarosz P, Salerno FR, Lemoine S, McIntyre CW. Impact of expanded hemodialysis using medium cut-off dialyzer on quality of life: Application of dynamic patient-reported outcome measurement tool. Kidney Med. 2021;3(6):992-1002.e1. 

  13. Bolton S, Gair R, Nilsson LG, Matthews M, Stewart L, McCullagh N. Clinical assessment of dialysis recovery time and symptom burden: Impact of switching hemodialysis therapy mode. Patient Relat Outcome Meas. 2021;12:315-321.

  14. Lim JH, Park Y, Yook JM, et al. Randomized controlled trial of medium cut-off versus high-flux dialyzers on quality of life outcomes in maintenance hemodialysis patients. Sci Rep. 2020;10(1):1-11.